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KMID : 0379120170450030212
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Korean Journal of Mycology
2017 Volume.45 No. 3 p.212 ~ p.223
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Screening of Anti-inflammatory Compound-producing Wild Yeasts and Their Microbiological Characteristics
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Bae Sang-Min
Han Sang-Min
Lee Jong-Soo
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Abstract
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To screen for potent anti-inflammatory compound-producing yeasts, we evaluated nitric oxide production inhibitory activities in RAW 264.7 macrophage cells using cell-free extracts from 182 non-pathogenic yeasts. YJ36-1 and YJ34-2 showed high inhibitory activities of 57.4% and 47.0%, respectively. The microbiological characteristics of these yeasts were investigated. YJ36-1 formed ascospores and pseudomycelium. This species grew well at 25°C in yeast extract- peptone-dextrose (YPD) medium, vitamin-free medium, and 5% NaCl-containing YPD medium. YJ34-2 was an asporogenous yeast and did not form pseudomycelium. This strain also grew well at 30°C in YPD medium, vitamin-free medium, and 5% NaCl-containing YPD medium.
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KEYWORD
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Anti-inflammatory, Nitric oxide inhibitor, RAW264.7, Wild yeast
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